Terpenes are fragrant oils secreted alongside cannabinoids like THC and CBD, they can also modify/tame their effects. Some popular strains tend to express higher levels of the terpene Limonene. So let’s learn a bit about this interesting aromatic molecule and why it’s so special.

d-Limonene is a monoterpene. Interestingly it’s not unique to cannabis and is also common in lemon and other citrus essential oils. It is the second most widely distributed terpenoid in nature.

The terpene Limonene is what gives citrus fruits, such as lemons their beautiful aroma and flavour , when combined with naturally occurring fruit sugar(fructose) the aroma and flavor goes from tart citrus to sweet and delicious. Limonene is found in large quantities in many legendary cup winning strains of cannabis such as Tangie, Orange bud, Super lemon haze, lemon skunk and California orange. Studies with varying methodology and dosing in citrus oils in mice suggest it to be a powerful anxiolytic (anxiety relieving) agent, increasing serotonin in the prefrontal cortex, and dopamine (DA) in hippocampus mediated via 5-HT1A .An attribute we feel here at Synergy of Nature is why strains containing high levels of Limonene may be so popular amongst the medical cannabis community. Not just for its distinct and delicious aroma but for the notable anti-anxiety effects.

Compelling confirmatory evidence in humans was provided in a clinical study in which hospitalized depressed patients were exposed to citrus fragrance in ambient air, with subsequent normalization of Hamilton Depression Scores, successful discontinuation of antidepressant medication in 9/12 patients and serum evidence of immune stimulation (CD4/8 ratio normalization). Limonene has shown to produce apoptosis of breast cancer cells, and was employed at high doses in Phase II RCTs. Subsequent investigation in cancer treatment has centred on its immediate hepatic metabolite, perillic acid, which demonstrates anti-stress effects in rat brain . A patent has been submitted, claiming that limonene effectively treats gastro-oesophageal reflux . Citrus EOs containing limonene proved to be an effective treatment for dermatophytes, a fungus that grows on skin, hair and nails. Citrus EOs with terpenoid profiles resembling those in cannabis demonstrated strong free radical scavenging anti-aging properties giving strong support to the human bodys immune system at the cellular level.

So here we have it another non-psychoactive component of the cannabis plant that’s proven to have be a safe and natural form of healing, both mentally and physically.

If you want a quick dose of limonene and there aren’t any of the above mentioned cannabis strains available. We have found that lemonade prepared with the whole lemon (Mediterranean-style lemonade) which includes the peel, contains very high levels of d-limonene. This can produce a lemonade with as much as 500mg of d-limonene per 1000ml. Just make sure to buy certified organic lemons

Here is a quick and easy recipe we use for a quick, tasty and mentally refreshing hit of d-limonene. You can also add a tablespoon of minced fresh ginger for added flavour and health promoting agents.


  • 1000ml of high alkaline water such as Evian
  • ½ a cup (120ml) of either Coconut nectar, maple syrup, stevia or agave nectar
  • 1 cup (240ml) of freshly squeezed organic lemon juice
  • 1 whole organic lemon, skin on and scrubbed clean
  • 1 tablespoon of minced ginger(optional)


  • Throw all your ingredients into a blender and blast until the whole lemon is completely pulverized
  • Transfer to large container add ice, soda water and 1 more freshly cut whole lemon.
  • Enjoy


D-limonene benefits at a glance

  • Anti-anxiety
  • Anti-depressant
  • Anti-fungal
  • Increases seratonin levels
  • Produces apoptosis of breast cancer cells
  • Treats gastro-oesophageal refux
  • Immunostimulant
  • Free radical scavenger
  • Anti-aging

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References- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/

Terpenes: The Flavour of cannabis aromatherapy


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